Back once more to create a difference! 3rd Annual Congress on Epigenetics & Chromatin commencing on April calendar month 23-24, 2020 in Berlin, Germany with the theme “Innovation & Discoveries in fields of Epigenetics & Chromatin will lead to be better future”Epigenetics 2020 would supply a good chance for community to depict their analysis work. Collaborating within the International conference are going to be a beautiful likelihood to fulfil eminent personalities within the field of Epigenetics in Clinical Practice, Epigenetic Biomarkers in Cancer, Chromatin Immunoprecipitation, Structure and Function of Chromatin, Chromatin Remodelling, Chromatin and Epigenetics, Immunology in the epigenetics specialist and understand a lot of concerning the advancements within the field.
· Engage with extraordinary students across the planet.
· The sessions of Epigenetics Congress set an extremely innovative and a precious contribution to our medical professions
· Act as a career tips for young researches and motivates them by young investigator awards.
· Perfect Platform for world networking through Epigenetics Conferences.
Benefits of the speaker:
- Accepted Abstracts will be published in PubMed, MEDLINE, ProQuest, SCOPUS, EBSCO, CAS, Hinari, Index Copernicus, Google Scholar, SCIRUS, DOAJ indexed journals
- Each abstract will receive a DO provided by CrossRef
- Global Exposure of your Research
- Networking with Experts across the globe
- Speaker and Abstract pages created in Google under your name will attract worldwide acknowledgment to your profile and research and it will be visible to 35K researchers across the globe
Benefits of Publishing:
- Through Open Access publication, authors benefit in several ways
- Standards of high-quality, rapid peer-review and production
- Enhances visibility and presence of the author due to free dissemination and frequent citation
- Liberal licensing and re-use policy through Creative Commons license
- Easy and immediate Online access
- High Impact factor and chances of getting cited thus enhance the authors API Index
Why Epigenitics 2020?
Conduct displays, distribute data, meet with current and potential scientists, create a splash with new drug developments and receive name recognition at this 2-day event.
World-renowed speakers, the foremost recent techniques, developments and also the newest updates in pharmacovigilance as hallmarks of the conference.
A platform to place forth your ideologies and making certain its price networking and meeting along with your fellow colleagues and superiors Collaborations, Career development, Personal interaction that ends up in an optimistic future. Breaking your temperature isn’t straight forward, presenting speeches leading to self-analysis.
The Epigenetics 2020, Berlin Germany offers a platform for the Epigenetics & Chromatin and experts both from Industry and Academia working in various sub domains of Epigenetics & Chromatin the advanced technologies and image analysis in Epigenetics & Chromatin. Professionals from Epigenetics & Chromatin Laboratories, Hospitals, and Academics, Directors, Deans, Research Professionals, Laboratory heads, Lab managers, Lab technicians, Laboratory Professionals, Medical/ Biomedical scientists, Professors, Associate Professors, Assistant Professors, Research Practicing pathologist, Research Fellows, Medical students, Nurses, Residents, working in the arena of Epigenetics & Chromatin and its allied fields.
Peasant welcome back to all, we extend a warm invitation to attend the 3rd Annual Congress on Epigenetics & Chromatin which fames the past, cherish the present and mould the future to be slated on April 23-24, 2020 at Berlin, Germany.
This year with the unique theme on: “Innovation & Discoveries in fields of Epigenetics & Chromatin will lead to be better future” to nurture the wide range of professionals in the field of Epigenetic Diseases, Chromatin & its Dynamics, Immunology in the epigenetics.
Epigenetics Congress 2020 gives you foremost opportunity to reach the largest assemblage of participants all over the globe.
Join us the exclusive Epigenetics Congress 2020, the unique convention to bring together worldwide distinguished industrialists and academicians in the field of Epigenetics in Clinical Practice, Epigenetic Biomarkers in Cancer, Chromatin Immunoprecipitation, Structure and Function of Chromatin, Chromatin Remodelling, Chromatin and Epigenetics, Immunology in the epigenetics
Join, conduct presentations, exchange information’s and connect with the current eminent and potential scientists to explore more on Epigenetics Mechanism, Epigenetic Diseases, Cyto-epigenetic approaches, Chromatin & its Dynamics, Environmental Epigenetic Factor, Genetics & Epigenetic inheritance, Microbial Epigenetics, Plant Epigenetics, Toxic epigenetics, Cancer Epigenetics make an impact with new drug innovations, developments and receive name recognition and certificates signed by our world class eminent organizing committee at this two days event. World renowned speakers, the most advanced and recent techniques, developments and the newest updates in Epigenetic Diseases, Chromatin & its Dynamics, Immunology in the epigenetics are hallmarks of this conference.
Meet and Explore at Berlin, Germany.
Epigenetics Congress 2020
Sessions / Tracks
Track 1: Epigenetics
Epigenetics is the study of the chemical change of specific genes or gene-associated proteins of an organism. Epigenetic changes can define how the information in genes is expressed and used by cells. other way of looking epigenetics is like this the traditional genetics describes the way the DNA order in our genes are transferred from one generation to the next generation, epigenetics describes transfer on the way the genes are used. To make a computer technology, think of epigenetics as data, information describing and ordering the underlying data
Track 2: Epigenetics Mechanism
Epigenetic mechanisms that helps to regulate gene activity in the CNS to be involved exclusively in developmental processes or in disease states. Recent work states that these mechanisms, mainly for post-translational changes of histones and repulsion changes of DNA, remain labile through the lifespan and are altered by experiences.
Epigenetic mechanisms are useful for controlling gene expression and chromatin designing in mammalian cells, and not surprisingly they play critical roles in both normal cardiac development and heart diseases. Epigenomics is the study of epigenetic features at a genome-wide level.
Track 3: Epigenetic Diseases
Epigenetic changes are responsible for human diseases, including Fragile X syndrome, Angelman’s syndrome, Prader-Willi syndrome, and various cancers. Abbreviations: ATR-X syndrome, alpha-thalassaemia, mental retardation syndrome, X linked; BWS, Beckwith–Wiedemann syndrome; CREB, response-element-binding protein; HAT, histone acetyltransferase; HMT, histone methyltransferase; ICF, immunodeficiency, centromeric region instability and facial anomalies syndrome; UTR, untranslated region.
The role of epigenetics in human diseases has been founded from a half of century ago. In the last decade, especially in complicated disorders such as behaviour plasticity, memory, cancer, autoimmune disease, and addiction as well as neurodegenerative and psychological disorders
Track 4: Cyto-epigenetic approaches
The combination of cytogenetic & epigenetic approaches in chronic lymphocytic leukemia improves prognosis prediction for patients. Cyto genetics is study of chromosomal structure, location and function in cells. Modern cytogenetic approaches are enable to label the chromosomal location of any gene using different colored dots, examine cells from any type of tissue (even tumour cells), identify cells that have lost or gained a specific chromosome & determine whether specific regions of chromosomes have been lost or gained without ever looking at the chromosomes under a microscope.
· Cancer cyto genetics
· Fluorescent in situ hybridization
· Molecular cyto genetics
Track 5: Chromatin & its Dynamics
The dynamics of chromatin has long been of interest to geneticists and cell biologists. For example, the question of whether chromosome rearrangements observed during the pairing of meiotic homologs in maize and Neurospora require special motile machinery, or whether they move by diffusion. The development of fluorescent live cell imaging techniques in recent decades has allowed for chromatin dynamics to be studied in the live cells of a wide range of organisms from yeasts to insects and mammals. When huge chromatin and centromeres studied on the scale of the nucleus, excluding apparent curvilinear chromosome movements that have been attributed to nuclear rotation
Track 6: Environmental Epigenetic Factor
In last century, it was known that DNA by itself does not determine all characteristics of an organism, including humans. The environment, stress one perceives, and nutrition, play a vital part in determining the response of an organism, as much as the DNA itself. Thus, it is known now that both nature (genetic makeup) and nurture (environmental factors) play equally important roles in the responses observed both at the cellular and organism levels.
Thus, human beings are affected by both genetic and epigenetic factors. Some environmentally induced changes in the epigenome are recorded in genomic DNA methylation patterns for up to three generations.
Track 7: Genetics & Epigenetic inheritance
An important set of phenomena, termed epigenetic inheritance, seem to be due to heritable alterations in which the DNA sequence itself is unchanged. Indeed, it is likely that these phenomena constitute another, poorly understood level of gene control. Examples of epigenetic inheritance in which the activity state of a gene depends on its genealogical history are paramutation and parental imprinting.
Epigenetic inheritance is an unconventional finding. It goes averse the idea that inheritance happens only through the DNA code that passes from parent to offspring. It means a parent's experiences, in the form of epigenetic tags, can be passed down to future generations.
Track 8: Microbial Epigenetics
The bacteria can affect the chromatin structure and transcriptional program of host cells by influencing diverse epigenetic factors. Bacterial & Viral infections are involved in the development of human cancers, such as liver, cervical, head and neck, nasopharyngeal and gastric cancers.
DNA methylation affects many biological processes in microbes and may play a role in pathogenicity and virulence. methyltransferase & DNA methylation specificities is possible during long-read sequencing.
· Bacteriophage Infection
· Bacterial Virulence
Track 9: Plant Epigenetics
The study of epigenetics in plants has a long history, from starting descriptions of non-Mendelian gene behaviors to seminal discoveries of chromatin-modifying proteins and RNAs that mediate gene silencing in most eukaryotes, including humans. Genetic screens in the model plant Arabidopsis have been particularly identifying more than 130 epigenetic regulators. The diversity of epigenetic in plants is remarkable, presumably contributing to the phenotypic plasticity of plant postembryonic development and the ability to survive and reproduce in unpredictable environments.
Track 10: Toxic epigenetics
In the mammalian life cycle evaluates the evidence for environmentally induced epigenetic toxicity in human cohorts and rodent models and highlights the research considerations and implications of this emerging knowledge for public health and regulatory toxicology. Hundreds of studies investigated toxicity, few demonstrated a mechanistic association among specific environmental exposures, epigenetic changes and adverse health outcomes in human epidemiological cohorts and/or rodent models. While, small body of evidence is highly composed of investigative in high-dose range studies, it does set a precedent for the existence of environmentally induced epigenetic toxicity
Track 11: Cancer Epigenetics
Cancer epigenetics is study of somatically changes to molecular processes that effect the flow of information between the DNA of cancer cells and their gene expression patterns. This includes comparative (tumour cell versus normal cell) investigation of nuclear organization, DNA methylation, histone modification and the consequences of genetic mutations in genes encoding epigenetic regulators.
The initiation and advance of cancer, traditionally seen as a genetic disease, is now realized to involve epigenetic abnormalities along with genetic alterations
Track 12: Epigenetics in Clinical Practice
Randomized trials have clearly demonstrated that the hypomethylating agents azacitidine and decitabine are more effective than 'best supportive care'(BSC) in reducing transfusion frequency in 'low-risk' myelodysplasia (MDS) and in prolonging survival compared with BSC or low-dose ara-C in 'high-risk' MDS or acute myeloid leukemia (AML) with 21-30% blasts. They also appear equivalent to conventional induction chemotherapy in AML with >20% blasts and as conditioning regimens before allogeneic transplant (hematopoietic cell transplant, HCT) in MDS.
Track 13: Epigenetic Biomarkers in Cancer
Epigenetic regulation is involved almost all growth processes of mammalian cells from fertilisation, implantation, and differentiation during embryonic advancement to aging and carcinogenesis. Different stages of development are characterized by differences in epigenetic signatures, and variations in epigenetic patterns may also be associated with specific stages of disease. Carcinogenesis is a multistep process; the detection of changes in epigenetic profiles can be exploited to differentiate not only between different types of malignancies but also between different stages of cancer progression. Epigenetic biomarkers hold great promise to become more conclusive diagnostic and prognostic biomarkers for different cancers. DNA methylation is the most studied area of epigenetics; DNA methylation biomarkers will play a prominent role. Epigenetic regulation plays a major role in cancer formation, and analysis of epigenetic biomarkers has great potential to become clinically relevant.
Track 14: Chromatin Immunoprecipitation
Chromatin immunoprecipitation (ChIP) is a technique it determines a protein of interest interacts with a specific DNA sequence. This technique is often used to study the repertoire of sites on DNA that are bound by particular transcription factors or by histone proteins, and to look at the precise genomic locations of various histone modifications (including acetylation, phosphorylation, or methylation). ChIP can be used to analyse the presence of protein-DNA interaction at steady state, Protein and associated chromatin are temporarily cross-linked in live cells or tissues (using formaldehyde or UV) and sheared using enzymatic digestion
Track 15: Structure and Function of Chromatin
The function of chromatin is to systematic package DNA into a small volume to fit into the nucleus of a cell and protect the DNA structure and sequence. Packaging DNA into chromatin allows for mitosis and meiosis, stops chromosome breakage and controls gene expression and DNA replication.
DNA wraps around the histone proteins to form nucleosomes, it turn couple to become the chromatin fiber.
1) Unpackaged DNA.
2) DNA wrapped around histone octamers to form nucleosomes.
3) Nucleosomes compacted into a chromatin fiber.
Track 16: Chromatin Remodelling
The variety of chromatin remodeling complexes that exist allow for a number of different mechanisms to remodel chromatin. Remodelers can slide nucleosomes, eject histone octamers, and replace dimers . These work require breakage of all 14 histone-DNA contacts and require approximately 12–14 kcal mol?1 (Gottesfeld and Luger 2001). All chromatin remodeler ATPases are members of the SF2 family of DEAD/H-box helicase/tranlocases and are in fact ATP-dependent DNA translocases (Cairns 2007; Saha et al. 2002; Whitehouse et al. 2003). Remodelers share common properties but are dedicated for specific tasks.
Track 17: Chromatin and Epigenetics
The epigenetic regulation of chromatin structure and composition has been studied molecularly in specific DNA-dependent processes. epigenetics play important global roles in moulding and maintaining cell identity, and in patterning the body plan during normal development. The alterations in epigenetic regulation are involved in many diseases, including cancer. The advances in our understanding of the impact of epigenetics in development and disease were discussed at a recent Keystone symposium. The importance of molecular machines that act on chromatin to regulate gene expression has fuelled a great interest in this field. it clear that epigenetics does not only affect the expression of individual genes.
Track 18: Immunology in the epigenetics
Recently, it has been well documented that epigenetic mechanisms like DNA methylation and histone changes control the expression of immune system-related genes, changing the development of the innate and adaptive immune responses. An in-depth knowledge of these epigenetic mechanisms could balance the immune response after transplantation and to develop new therapeutic strategies . The detection of epigenetic marks in main immune genes could be useful as biomarkers of rejection and progression among transplanted patients.
The Cancer market is one of the fastest-growing segments of the pharmaceutical industry and is expected to remain the top therapy segment during the foreseeable future. Biotechnology and pharmaceutical companies are entering the market with innovative treatments that combined with existing medicines and increased pharmaceutical cancer research activities; aim to deliver a new standard of cancer care.
The worldwide business sector of Epigenetics is segmented in light of products, research territories and geology. By product, the business sector incorporates instruments, catalysts and consumables, packs and reagents. Catalysts are further sub segmented into protein-modifying enzymes, DNA-modifying enzymes, and RNA-modifying enzymes.
On the basis of application, the market is bifurcated into cancer and non-cancer. Cancer is further sub-segmented into solid tumors & liquid tumors and non-cancer is further categorized into inflammatory diseases, metabolic diseases, infectious diseases, cardiovascular diseases, developmental biology, drug discovery, and other applications. Cancer is the second driving reason for death comprehensively and represented 8.8 million passing in 2015. Lung, prostate, colorectal, stomach and liver growth are the most widely recognized sorts of disease in men, while bosom, colorectal cancer, lung cancer, cervix cancer and stomach malignancy are the most well-known among women. Cancer influences everybody – the youth and elder, the rich and poor, men, women and speaks to an enormous weight on patients, families and social orders. However, a considerable lot of these passing’s can be kept away from. Between 30-half of growths are preventable by sound way of life decisions, for example, evasion of tobacco and general wellbeing measures like inoculation against tumor causing diseases. Others can be distinguished early, treated and cured. Indeed, even with late stage disease, the anguish of patients ought to be assuaged with great palliative care. The financial effect of disease is critical and is expanding .The aggregate yearly monetary cost of cancer growth is around US$ 1.16 trillion. In 2015 around 8.8 million individuals kicked the bucket from cancer growth about 1 out of 6 worldwide passing’s. The quantity of new cases is required to ascend by around 70% throughout the following 2 decades. Just 1 of every 5 low-and center salary nations have the important information to drive disease strategy. On the basis of end user, the market is classified into cancer academic & cancer research institutes, pharmaceutical companies, biotechnology companies & contract research organizations (CROs). Geographically, the market is analysed across Europe, North America, Asia-Pacific, and LAMEA.
Global Epigenetics Market was valued at $555 million in 2016, and is estimating to reach at $1,321 million by 2023.